絡石

出自台灣有毒中草藥毒性資料庫

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2. 趙中振, 蕭培根. 當代藥用植物典. In Edition 香港賽馬會中藥研究院 2006; 471.
2. 趙中振, 蕭培根. 當代藥用植物典. In Edition 香港賽馬會中藥研究院 2006; 471.
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3. Tan XQ, Guo LJ, Qiu YH et al. Chemical constituents of Trachelospermum jasminoides. Nat Prod Res 2010; 24: 1248-1252.
+
3. Tan XQ, Guo LJ, Qiu YH et al. [http://www.ncbi.nlm.nih.gov/pubmed/20645212 Chemical constituents of ''Trachelospermum jasminoides''.] Nat Prod Res 2010; 24: 1248-1252.
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4. Bai L, Chen W, Wang X et al. Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. J Cell Biochem 2009; 108: 1125-1131.
+
4. Bai L, Chen W, Wang X et al. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071149/ Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells.] J Cell Biochem 2009; 108: 1125-1131.
-
5. Sun S, Wang X, Wang C et al. Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med 2011; 77: 141-145.
+
5. Sun S, Wang X, Wang C et al.[http://www.ncbi.nlm.nih.gov/pubmed/20717870 Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.] Planta Med 2011; 77: 141-145.
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6. Susanti S, Iwasaki H, Itokazu Y et al. Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L. J Nat Med 2012; 66: 614-621.
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6. Susanti S, Iwasaki H, Itokazu Y et al. [http://www.ncbi.nlm.nih.gov/pubmed/22350142 Tumor specific cytotoxicity of arctigenin isolated from herbal plant ''Arctium lappa'' L.] J Nat Med 2012; 66: 614-621.
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7. Matsuzaki Y, Koyama M, Hitomi T et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep 2008; 19: 721-727.
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7. Matsuzaki Y, Koyama M, Hitomi T et al. [http://www.ncbi.nlm.nih.gov/pubmed/18288407 Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.] Oncol Rep 2008; 19: 721-727.
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8. Anter J, Romero-Jimenez M, Fernandez-Bedmar Z et al. Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid. J Med Food 2011; 14: 276-283.
+
8. Anter J, Romero-Jimenez M, Fernandez-Bedmar Z et al. [http://www.ncbi.nlm.nih.gov/pubmed/21182433 Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid.] J Med Food 2011; 14: 276-283.
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在2012年10月30日 (二) 07:43的最新修訂版本

中英文學名 科別 毒性 症狀

基本資料

科別

夾竹桃科Apocynaceae[1, 2]

屬名

絡石屬 Trachelospermum'[2]'

中文學名

絡石

拉丁學名

Trachelospermum jasminoides (Lindl.) Lem.[2]

英文名稱

Chinese Starjasmine[2]，Fetid star jasmine[1]

中文俗名

絡石，台灣白花藤[1]


植物圖片

絡石02.jpg

絡石葉1

絡石-種子1.jpg

絡石種子1

絡石-實6.jpg

絡石種子2

絡石-實1.jpg

絡石果實

絡石-花.jpg

絡石花

絡石-葉2.jpg

絡石葉2


絡石簡介

藤本，光滑[1]


外觀簡述

葉

單葉對生，具短柄，葉片長7-10公分，寬2-4公分，橢圓至倒披針形，葉基鈍形，葉緣全緣，側脈5-7對[1]

花

呈聚繖花序，總梗較葉片長，花萼披針形，頂端反捲，花冠倒三角形，白色[1]

果實

蓇葖果[1]


產地

遍及中國各省區；朝鮮半島、日本、越南也有分佈[2]，台灣產於低至中海拔森林[1]


使用情況

中醫藥認為絡石藤具有祛風通絡，涼血消腫等功效[2]


活性成份

莖＆葉[2]

  • 1. 木脂素類arctiin, arctigenin, matairesinol, trachelogenin, nortrachelogenin, tracheloside, et al
  • 2. 生物鹼類conoflorine, coronaridine, boacangine, apparicine, ibogaine, vobasine, et al
  • 3. 黃酮類apigenin, luteolin, cosmociin, rhoifolin
  • 4. 三萜類trachelosperosides, trachelosperogenin B, 3β-O-D-glucopyranoside quinovic acid


活性研究

  • 1. Luteolin potently blocks TNF-induced NF-kB activation，促進癌細胞的凋亡，有抗癌的活性[4]
  • 2. Arctigenin會抑制癌細胞的glucose-regulated protein-78 (GRP78)，進而抑制UPR pathway,導致癌細胞無法獲得glucose而抑制增生[5]


毒性研究

  • 症狀
    • 絡石的毒性案例很少見，在Pacific Island Ecosystems at Risk (PIER)的評估中屬於Low risk，但在Poisonous Plants of North Carolina中歸類為未知的毒物，由於含相同成分但不同植物中已經在動物或體外毒性實驗的研究證實，高劑量有細胞的毒性[6]。

  • 有毒成分
    • 1. arctiin[7]
    • 2. apigenin[8]

  • 中毒劑量
    • Apigenin在體外試驗(HL-60 Leukemia cells): 0.75-3.87mM有＜50%的存活率(trypan blue)[8]
    • Arctiin在體外試驗(HaCaT cell): 100-250 μM 48 h significantly increased the percentage from 38.2 to 48.8% in the G1 phase[7]

  • 機轉
    • arctiin會抑制cyclin D1 protein[7]的蛋白表現，進一步抑制細胞的生長

  • 細胞毒性
    • Acrtiin, apigenin


毒性分級

級數C1


參考文獻

1. 鄭武燦. 台灣植物圖鑑. In Edition 國立編譯館 2000.

2. 趙中振, 蕭培根. 當代藥用植物典. In Edition 香港賽馬會中藥研究院 2006; 471.

3. Tan XQ, Guo LJ, Qiu YH et al. Chemical constituents of Trachelospermum jasminoides. Nat Prod Res 2010; 24: 1248-1252.

4. Bai L, Chen W, Wang X et al. Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. J Cell Biochem 2009; 108: 1125-1131.

5. Sun S, Wang X, Wang C et al.Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med 2011; 77: 141-145.

6. Susanti S, Iwasaki H, Itokazu Y et al. Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L. J Nat Med 2012; 66: 614-621.

7. Matsuzaki Y, Koyama M, Hitomi T et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep 2008; 19: 721-727.

8. Anter J, Romero-Jimenez M, Fernandez-Bedmar Z et al. Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid. J Med Food 2011; 14: 276-283.


中英文學名 科別 毒性 症狀
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